Select Recent Publications

2020

  •  Singh MB and Sartor GC*. (2020) BET bromodomains as novel epigenetic targets for brain health and disease. Neuropharmacology. (in press). *Corresponding author

2019

  • Sartor GC*. (2019) Epigenetic pharmacotherapy for substance use disorder. Biochemical Pharmacology. 168:269-274. PMC6733674. *Corresponding author

  • Sartor GC*, Malvezzi A, Kumar A, Andrade N, Wiedner H, Vilca S, Janczura K, Bagheri A, Al-Ali H, Powell SK, Brown P, Volmar CH, Foster T, Zeier Z, and Wahlestedt C. (2019) Enhancement BDNF expression and memory by HDAC inhibition requires BET bromodomain reader proteins.               Journal of Neuroscience 39(4): 612-626. PMC6343644. *Corresponding author

2018

  • Janczura KJ, Volmar CH, Sartor GC, Ricciardi NR, Lambert G, Brothers SP, Wahlestedt C.  Inhibition of Histone Deacetylase 3 Activity with RGFP-966 Reverses Alzheimer’s Disease (AD)-related Pathological Hallmarks and Alleviates Memory Impairment in the Triple Transgenic AD Mouse Model. (2018) Proceedings of the National Academy of Sciences, 115(47):E11148-E11157. PMC6255210 

  • W, Wang H,  Wei JQ, Sartor GC, Bao M, Pierce C, Wahlestedt C, Dykxhoorn D and Dong C.  (2018) Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p—Me1—ROS Pathway.  Hypertension, 71(4):752-760.  PMC5843539

2017

  • Volmar CH,  Salah-Uddin H, Janczura JK, Halley P, Lambert G, Wodrich A, Manoah S, Patel N, Mehta M, Sartor GC, Mehta N, Miles N,  Desse S, Dorcius D, Wahlestedt C. (2017)  M344 promotes non-amyloidogenic amyloid precursor protein processing while normalizing Alzheimer’s disease genes and improving memory.  Proceedings of the National Academy of Sciences, 114(43): E9135-144.  PMC5664514.

  • Sartor GC, Powell SK, Lin DY, Velmeshev D, Magistri M, Wiedner HJ, Malvezzi AM, Faghihi MA and Wahlestedt C. (2017)  Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens.  Molecular and Cellular Neuroscience, (85): 183-189.  PMC5698162.

2016

  • Sartor GC, Powell SK, Brothers SP and Wahlestedt C. (2016) Nociceptin receptor activation does not alter acquisition, expression, extinction and reinstatement of conditioned cocaine preference in mice. Brain Research, 1632: 34-21.  PMC4733396.

  • Magistri M, Velmeshev D, Makhmutova M, Patel P, Sartor GC, Volmar CH, Wahlestedt C, Faghihi MA. (2016) The BET-bromodomain inhibitor JQ1 reduces inflammation and tau phosphorylation in the brain of the 3xTg model of Alzheimer’s disease.  Current Alzheimer Research, 13(9): 985-95.  PMC5026248.

  • Maruf A, Aziz A, Brothers SP, Sartor G, Heilig M, Wahlestedt C and Thorsell A. (2016) The Nociceptin/Orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: validation in rat models. Psychopharmacology (Berl), 233(19-20): 3553-63.  PMC5021736. 

2015

  • Sartor GC, Powell SK, Brothers SP and Wahlestedt C. (2015) Epigenetic readers of lysine acetylation regulate cocaine-induced plasticity.  Journal of Neuroscience, 35(45): 15062-72.  PMC4642238

2014

  • Sartor GC and Aston-Jones G (2014) Post-retrieval extinction attenuates cocaine memories.  Neuropsychopharamcology, 39(5):1059-65.  PMC3957116.

2012

  • Sartor GC and Aston-Jones G (2012) A septal-hypothalamic pathway drives orexin neurons and cocaine preference.   Journal of Neuroscience, 32(13):4623-31. PMC3350779.

  • Sartor GC, St Laurent G 3rd, Wahlestedt C.  (2012) The emerging role of non-coding RNAs in drug addiction.  Frontiers in Genetics, 3: 106. PMC3381216.

  • Sartor GC and Aston-Jones G (2012) Regulation of ventral tegmental area by bed nucleus of the stria terminalis is required for expression of cocaine preference.  European Journal of Neuroscience. 36: 3549-58. PMC3514627.

  • Mahler SV, Smith RJ, Moorman DE, Sartor GC, Aston-Jones G (2012)  Multiple roles for orexin in addiction to drugs of abuse. Progress in Brain Research, 198:79-121. PMC3643893.

  • Reissner KJ, Sartor GC, Vazey EM, Dunn TE, Aston-Jones G, Kalivas PW. (2012) Use of vivo-morpholinos for control of protein expression in the adult rat brain.  Journal Neuroscience Methods, 203(2):354-60. PMC3857614.

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The Sartor Lab

Department of Pharmaceutical Sciences

School of Pharmacy

University of Connecticut

69 North Eagleville Road

Storrs, CT 06269-3092

Email: gregory.sartor@uconn.edu

Phone: 860-486-3655